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Error send from on premise exchange to EXCHANGE online 365

Hi,

 

Having a major issue with users from our on-premise exchange sending to our office 365 environment. Some users are able to send to addresses from the on-premise environment to the office 365 environment whereas other recieve NDR with the following error.

 

#550 4.4.7 QUEUE.Expired; message expired in unreachable destination queue. Reason: The mailbox recipient does not have a mailbox database ## exchange 2010

 

Im racking my brain to find a fix to this issue. Any ideas?

 

Thanks

 

Shane


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